Triethylamine → 6-(5-Phenyl-thiazol-2-ylamino)-pyridine-2-carbaldehyde

HRID 1355498노트

반응식

HRID 1355498 반응식
[C:1]1([C:7]2[S:11][C:10]([NH:12][C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([CH2:19][OH:20])[N:14]=3)=[N:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.N1C=CC=CC=1.S(=O)(=O)=O.C(N(CC)CC)C>CS(C)=O.O>[C:1]1([C:7]2[S:11][C:10]([NH:12][C:13]3[N:14]=[C:15]([CH:19]=[O:20])[CH:16]=[CH:17][CH:18]=3)=[N:9][CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

6

반응물 3

HCID 8471TriethylamineHCID 168533Sulfur trioxide-pyridineHCID 18506891[2-(5-Phenyl-thiazol-2-ylamino)-pyridin-6-yl]-methanol2회

생성물 1

HCID 185068596-(5-Phenyl-thiazol-2-ylamino)-pyridine-2-carbaldehyde

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 962Water용매

실험 절차

[2-(5-Phenyl-thiazol-2-ylamino)-pyridin-6-yl]-methanol (6-4), 0.60 g (2.1 mmol) Sulfur trioxide-pyridine (1.01 g, 6.36 mmol) was dissolved in 10 mL anhydrous DMSO and the resulting solution was stirred for 10 min. Triethylamine (2.45 mL, 17.6 mmol) was added followed by addition of [2-(5-Phenyl-thiazol-2-ylamino)-pyridin-6-yl]-methanol (6-4), (0.60 g, 2.1 mmol). After 30 min the reaction was diluted with water and the resulting precipitate was filtered and washed with water to afford the titled compound.

후처리

  1. filtrationthe resulting precipitate was filtered
  2. washwashed with water

출처 및 근거

ORD 기록
ord-f00b4bac07a74dd19ef5663375215d13
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06586424B2

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