2-(Benzenesulfonyl)-3-phenyloxaziridine → 2-(Methylsulfinyl)pyrimidine

HRID 1355683

반응식

HRID 1355683 반응식
[CH3:1][S:2][C:3]1[N:8]=[CH:7][CH:6]=[CH:5][N:4]=1.C1(C2[O:17]N2S(C2C=CC=CC=2)(=O)=O)C=CC=CC=1>ClCCl>[CH3:1][S:2]([C:3]1[N:8]=[CH:7][CH:6]=[CH:5][N:4]=1)=[O:17]

참가 물질

4

반응물 2

HCID 3204052-(Benzenesulfonyl)-3-phenyloxaziridineHCID 5227722-(Methylsulfanyl)pyrimidine

생성물 1

HCID 114008322-(Methylsulfinyl)pyrimidine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The methylsulfanyl-pyrimidine compound of formula (83) is reacted with an oxidising agent, preferably 3-phenyl-2-(phenylsulfonyl)oxaziridine, in an organic solvent, preferably dichloromethane, at room temperature. The product of formula (84), a methanesulfinyl-pyrimidine derivative, is isolated by conventional means, and preferably reacted in the next step without further purification. The product of formula (84) may, however, be additionally purified by means of chromatography or recrystallisation.

출처 및 근거

ORD 기록
ord-224b15c6ee9741c48c8a184c2ab8484f
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06586441B2

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