참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | (1-Ethoxycyclopropoxy)trimethylsilane | HCID 2734686 | — |
| 반응물 | Sodium cyanoborohydride | HCID 5003444 | — |
| 반응물 | (4-Morpholin-4-ylmethyl-phenyl)piperazin-1-yl-methanone | HCID 59218186 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Bavisant | HCID 16061509 | — |
반응 단계
A solution of (4-morpholin-4-ylmethyl-phenyl)-piperazin-1-yl-methanone (0.128 g) in methanol (7.5 mL) was treated with (1-ethoxy-cyclopropoxy)-trimethyl-silane (1.5 mL), acetic acid (0.2 mL), and NaBH3CN (˜400 mg). The mixture was heated at 60° C. for 18 h, and then was cooled to room temperature and concentrated. The residue was diluted with 1 N NaOH and extracted with CH2Cl2. The organic layer was dried (Na2SO4) and concentrated. The residue was purified by column chromatography (SiO2) to yield the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07728129B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_06 |
|---|
| ORD ID | ord-7ed386d7e56a467c9382415fc0799b9b |
|---|
| 출처 메모 | uspto-grants-2010_06 |
|---|
