反应详情

温度

60 °C

A solution of (4-morpholin-4-ylmethyl-phenyl)-piperazin-1-yl-methanone (0.128 g) in methanol (7.5 mL) was treated with (1-ethoxy-cyclopropoxy)-trimethyl-silane (1.5 mL), acetic acid (0.2 mL), and NaBH3CN (˜400 mg). The mixture was heated at 60° C. for 18 h, and then was cooled to room temperature and concentrated. The residue was diluted with 1 N NaOH and extracted with CH2Cl2. The organic layer was dried (Na2SO4) and concentrated. The residue was purified by column chromatography (SiO2) to yield the title compound.

1. temperaturewas cooled to room temperature
2. concentrationconcentrated
3. additionThe residue was diluted with 1 N NaOH
4. extractionextracted with CH2Cl2
5. dry with materialThe organic layer was dried (Na2SO4)
6. concentrationconcentrated
7. customThe residue was purified by column chromatography (SiO2)