N-1-Naphthylethylenediamine dihydrochloride → 2-Amino-4-furan-2-yl-6-[2-(naphthalen-1-ylamino)-ethylamino]-pyrimidine-5-carbonitrile

HRID 1356001노트

반응식

HRID 1356001 반응식
[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[O:9][CH:10]=[CH:11][CH:12]=2)[C:5]([C:13]#[N:14])=[C:4](S(C)=O)[N:3]=1.Cl.Cl.[C:20]1([NH:30][CH2:31][CH2:32][NH2:33])[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:23]=[CH:22][CH:21]=1.C1CCN2C(=NCCC2)CC1>COCCOC>[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[O:9][CH:10]=[CH:11][CH:12]=2)[C:5]([C:13]#[N:14])=[C:4]([NH:33][CH2:32][CH2:31][NH:30][C:20]2[C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH:23]=[CH:22][CH:21]=2)[N:3]=1

참가 물질

5

반응물 3

HCID 15106N-1-Naphthylethylenediamine dihydrochlorideHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 185076922-Amino-4-(furan-2-YL)-6-(methylsulfinyl)pyrimidine-5-carbonitrile

생성물 1

HCID 185074602-Amino-4-furan-2-yl-6-[2-(naphthalen-1-ylamino)-ethylamino]-pyrimidine-5-carbonitrile

시약·촉매·용매 1

HCID 80711,2-Dimethoxyethane용매

실험 절차

From 2-amino-4-furan-2-yl-6-methanesulfinyl-pyrimidine-5-carbonitrile, N-(1-naphthyl)ethylendiamine dihydrochioride and DBU in DME. ES-MS m/e (%): 371 (M+H+, 100).

출처 및 근거

ORD 기록
ord-ddba208c7d69480b942cf9bdb0a79b6f
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06586441B2

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