1,8-Diazabicyclo(5.4.0)undec-7-ene → 2-Amino-4-(isoquinolin-3-yl-methoxy)-6-pyrazol-1-yl-pyrimidine-5-carbonitrile

HRID 1356162

반응식

HRID 1356162 반응식
[NH2:1][C:2]1[N:7]=[C:6](S(C)=O)[C:5]([C:11]#[N:12])=[C:4]([N:13]2[CH:17]=[CH:16][CH:15]=[N:14]2)[N:3]=1.[CH:18]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:21]=[C:20]([CH2:28][OH:29])[N:19]=1.C1CCN2C(=NCCC2)CC1>COCCOC>[NH2:1][C:2]1[N:7]=[C:6]([O:29][CH2:28][C:20]2[N:19]=[CH:18][C:27]3[C:22]([CH:21]=2)=[CH:23][CH:24]=[CH:25][CH:26]=3)[C:5]([C:11]#[N:12])=[C:4]([N:13]2[CH:17]=[CH:16][CH:15]=[N:14]2)[N:3]=1

참가 물질

5

반응물 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 12874869Isoquinolin-3-ylmethanolHCID 185075202-Amino-4-methanesulfinyl-6-pyrazol-1-yl-pyrimidine-5-carbonitrile

생성물 1

HCID 185076672-Amino-4-(isoquinolin-3-yl-methoxy)-6-pyrazol-1-yl-pyrimidine-5-carbonitrile

시약·촉매·용매 1

HCID 80711,2-Dimethoxyethane용매

실험 절차

From 2-amino-4-methanesulfinyl-6-pyrazol-1-yl-pyrimidine-5-carbonitrile, isoquinolin-3-yl-methanol and DBU in DME. ES-MS m/e (%): 366 (M+Na+, 60), 344 (M+H+, 100).

출처 및 근거

ORD 기록
ord-923d9552297144629b5295ff5ebc272a
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06586441B2

연결된 노트

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