Hydrochloric Acid → 5,7-Bis(1,1-dimethylethyl)-3-phenyl-(3H)-benzofuran-2-one

HRID 1356561

반응식

HRID 1356561 반응식
Cl.N[C:3]1[O:4][C:5]2[C:17]([C:18]([CH3:21])([CH3:20])[CH3:19])=[CH:16][C:15]([C:22]([CH3:25])([CH3:24])[CH3:23])=[CH:14][C:6]=2[C:7]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.C([OH:29])(C)C>>[C:22]([C:15]1[CH:16]=[C:17]([C:18]([CH3:21])([CH3:19])[CH3:20])[C:5]2[O:4][C:3](=[O:29])[CH:7]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)[C:6]=2[CH:14]=1)([CH3:23])([CH3:24])[CH3:25]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 113930882-amino-3-phenyl-5,7-di-tert-butyl-benzofurane2회

생성물 1

HCID 64553565,7-Bis(1,1-dimethylethyl)-3-phenyl-(3H)-benzofuran-2-one수율 85%

실험 절차

4.8 ml (9.58 mmol) of 2N HCl is added at room temperature to a solution of 3.08 g (9.58 mmol) of 2-amino-3-phenyl-5,7-di-tert-butyl-benzofurane [compound (301), Table 3, prepared according to Example 1a] in 10 ml iso-propanol and stirred at room temperature for 90 minutes. The precipitate is filtered and washed with isopropanol. Crystallization of the residue from isopropanol yields 2.62 g (85%) of 5,7-di-tert-butyl-3-phenyl-3H-benzofuran-2-one (compound (101), Table 1), m.p. 116-119° C.

후처리

  1. filtrationThe precipitate is filtered
  2. washwashed with isopropanol
  3. customCrystallization of the residue from isopropanol

출처 및 근거

ORD 기록
ord-cc353632eb014ed18f56b86ac22f1404
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06586606B2

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