Lithium Hydroxide → N-(Toluene4-sulfonyl)-L-prolyl-L-tryptophan

HRID 1356859노트

반응식

HRID 1356859 반응식
O.[C:2]1([CH3:19])[CH:7]=[CH:6][C:5]([S:8]([N:11]2[CH2:18][CH2:17][CH2:16][C@H:12]2[C:13]([OH:15])=O)(=[O:10])=[O:9])=[CH:4][CH:3]=1.Cl.C[O:22][C:23](=[O:36])[C@H:24]([CH2:26][C:27]1[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[NH:29][CH:28]=1)[NH2:25].[Li+].[OH-]>C1COCC1.O>[C:2]1([CH3:19])[CH:3]=[CH:4][C:5]([S:8]([N:11]2[CH2:18][CH2:17][CH2:16][C@H:12]2[C:13]([NH:25][C@H:24]([C:23]([OH:36])=[O:22])[CH2:26][C:27]2[C:35]3[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=3)[NH:29][CH:28]=2)=[O:15])(=[O:9])=[O:10])=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 3939Lithium HydroxideHCID 2734891Methyl tryptophanate hydrochlorideHCID 69463844N-tosyl-(s)-proline monohydrate

생성물 1

HCID 54463657N-(Toluene4-sulfonyl)-L-prolyl-L-tryptophan

시약·촉매·용매 1

HCID 21881883Oxolane--water (1/1)용매

실험 절차

N-(Toluene-4-sulfonyl)-L-proline hydrate was coupled to L-tryptophan methyl ester hydrochloride using the procedure described in Method 3. The title compound was prepared via hydrolysis of the methyl ester using LiOH in THF/water.

출처 및 근거

ORD 기록
ord-f6351ac89c7845769a0a4ea2ab675eec
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06586602B2

반응 노트

불러오는 중…