Lithium Hydroxide → HCID 18188087, 화합물

HRID 1357867노트

반응식

HRID 1357867 반응식
C([O:4][C:5]1[CH:6]=[C:7]([CH2:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH:8]=[C:9]([CH3:14])[C:10]=1[N+:11]([O-:13])=[O:12])(=O)C.[OH-].[Li+].C(OCC)(=O)C.[Cl-].[Na+]>CO.O>[OH:4][C:5]1[CH:6]=[C:7]([CH2:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH:8]=[C:9]([CH3:14])[C:10]=1[N+:11]([O-:13])=[O:12]

참가 물질

7

반응물 4

HCID 3939Lithium HydroxideHCID 5234Sodium ChlorideHCID 8857Ethyl AcetateHCID 18188096t-Butyl 3-acetoxy-5-methyl-4-nitrophenylacetate

생성물 1

HCID 18188087HCID 18188087, 화합물수율 104.2%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

A solution of t-butyl 3-acetoxy-5-methyl-4-nitrophenylacetate [0.5 g, Reference Example 17(a)] in methanol (6 mL) was treated with lithium hydroxide (0.2 g) in water (1.5 mL). After stirring for 2 hours the mixture was carefully acidified to pH 5 and then treated with ethyl acetate and sodium chloride. The organic layer was evaporated and the residue was dissolved in dichloromethane. This solution was dried and then evaporated to give the title compound (0.45 g) as a yellow green oil.

후처리

  1. customThe organic layer was evaporated
  2. dissolutionthe residue was dissolved in dichloromethane
  3. customThis solution was dried
  4. customevaporated

출처 및 근거

ORD 기록
ord-12a6c9d0dbe642348317d72218628742
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06593354B2

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