Hydrochloric Acid → HCID 131723149, 화합물

HRID 1357953노트

반응식

HRID 1357953 반응식
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[N:18]([CH2:19][CH3:20])[N:17]=[C:16]([CH2:21][CH3:22])[C:15]=2[CH3:23])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>CO>[ClH:24].[ClH:24].[CH2:19]([N:18]1[C:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[C:15]([CH3:23])[C:16]([CH2:21][CH3:22])=[N:17]1)[CH3:20]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 21912727HCID 21912727, 화합물

생성물 1

HCID 131723149HCID 131723149, 화합물수율 92%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 1-(t-butoxycarbonyl)-4-(1,3-diethyl-4-methyl-(1H)-pyrazol-5-yl)piperidine (348 mg) (from Step E) in 2.5 N HCl in methanol was stirred at rt for 16 h. The solution was concentrated and the resulting solid was suspended in ethyl acetate, filtered and dried to afford 293 mg (92%) of the title compound.

후처리

  1. concentrationThe solution was concentrated
  2. filtrationfiltered
  3. customdried

출처 및 근거

ORD 기록
ord-59e19765ea0c45c0805cffacbbc01c4c
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06593346B2

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