7-Amino-4-(3-bromoanilino)-6-nitroquinazoline → N4-(3-bromophenyl)-4,6,7-Quinazolinetriamine

HRID 1358272

반응식

HRID 1358272 반응식
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:12][C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([Br:19])[CH:14]=3)=[N:7][CH:8]=[N:9]2)=[CH:4][C:3]=1[N+:20]([O-])=O>CCO.[Fe]>[Br:19][C:15]1[CH:14]=[C:13]([CH:18]=[CH:17][CH:16]=1)[NH:12][C:6]1[C:5]2[C:10](=[CH:11][C:2]([NH2:1])=[C:3]([NH2:20])[CH:4]=2)[N:9]=[CH:8][N:7]=1

참가 물질

4

반응물 1

HCID 53282147-Amino-4-(3-bromoanilino)-6-nitroquinazoline

생성물 1

HCID 2426N4-(3-bromophenyl)-4,6,7-Quinazolinetriamine수율 65%

시약·촉매·용매 2

HCID 23925Iron촉매HCID 702Ethanol용매

실험 절차

Iron dust reduction of 7-amino-4-(3-bromoanilino)-6-nitroquinazoline (0.5 g, 1.4 mmol) in 65% aqueous EtOH containing sufficient aqueous HCl to ensure solubility gives 4-(3-bromoanilino)-6,7-diaminoquinazoline (0.30 g, 65%). 1H NMR (DMSO) δ9.14 (1H, s), 8.27 (1H, s), 8.23 (1H, brs), 7.85 (1H, d, J=8.0 Hz), 7.31-7.14 (2H, m), 7.29 (1H, s), 6.79 (1H, s), 5.73 (2H, brs), 5.13 (2H, brs).

출처 및 근거

ORD 기록
ord-0d1fb1785bee4cb3b05ddf7d05af90da
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06596726B1

연결된 노트

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