N4-(3-bromophenyl)-4,6,7-Quinazolinetriamine → N-(3-bromophenyl)pyrazino[2,3-g]quinazolin-4-amine

HRID 1358273

반응식

HRID 1358273 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][CH:20]=1)[NH:5][C:6]1[C:15]2[C:10](=[CH:11][C:12]([NH2:17])=[C:13]([NH2:16])[CH:14]=2)[N:9]=[CH:8][N:7]=1.O1CCO[CH:23](O)[CH:22]1O>CO>[Br:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][CH:20]=1)[NH:5][C:6]1[C:15]2[C:10](=[CH:11][C:12]3[N:17]=[CH:23][CH:22]=[N:16][C:13]=3[CH:14]=2)[N:9]=[CH:8][N:7]=1

참가 물질

4

반응물 2

HCID 2426N4-(3-bromophenyl)-4,6,7-QuinazolinetriamineHCID 961701,4-Dioxane-2,3-diol

생성물 1

HCID 5328246N-(3-bromophenyl)pyrazino[2,3-g]quinazolin-4-amine수율 84.1%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 4-(3-bromoanilino)-6,7-diaminoquinazoline (90 mg, 0.27 mmol) and 1,4-dioxane-2,3-diol (0.2 g, 1.6 mmol) [Venuti, M. C.; Synthesis, 1982, 61-63] in MeOH (20 mL) is stirred at room temperature overnight to give a precipitate of 4-(3-bromoanilino)pyrazino[2,3-g]quinazoline (80 mg, 83%).

출처 및 근거

ORD 기록
ord-9bc38be78ea04612aa042065386db123
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06596726B1

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