Water → 4-Hydrazinobenzenesulfonic acid morpholide

HRID 1358376노트

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HRID 1358376 반응식
F[C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.O.[NH2:18][NH2:19].O>CN1CCCC1=O>[NH:18]([C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1)[NH2:19]

참가 물질

5

반응물 3

HCID 962WaterHCID 24654Hydrazine hydrate (1:1)HCID 7553774-((4-Fluorophenyl)sulfonyl)morpholine

생성물 1

HCID 112998664-Hydrazinobenzenesulfonic acid morpholide

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

반응 조건

온도
100 °C

실험 절차

5 g of 4-fluorobenzenesulfonic acid morpholide were dissolved in 15 ml of N-methylpyrrolidone and mixed with 2.5 g of hydrazine hydrate, and the mixture was heated at 100° C. for 1 hour. After cooling to room temperature, 75 ml of water were added and the mixture was stirred at room temperature. After 2 hours, the solid was filtered off with suction and recrystallized from isopropanol.

후처리

  1. temperatureAfter cooling to room temperature
  2. filtrationthe solid was filtered off with suction
  3. customrecrystallized from isopropanol

출처 및 근거

ORD 기록
ord-32059fe74de94fbab9455921df158db1
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06596742B1

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