Oxalic Acid → 3-Nitro-phenethylamine oxalate
반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][C:11]#[N:12])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[C:13]([OH:18])(=[O:17])[C:14]([OH:16])=[O:15]>C1COCC1>[C:13]([OH:18])(=[O:17])[C:14]([OH:16])=[O:15].[N+:1]([C:4]1[CH:5]=[C:6]([CH:7]=[CH:8][CH:9]=1)[CH2:10][CH2:11][NH2:12])([O-:3])=[O:2]참가 물질
4
실험 절차
3-Nitrophenyl acetonitrile (6.486 g, 0.04 mol) was refluxed with borane-THF complex (40 mL, 0.04 mole) in anhydrous THF (80 mL) for 45 min under argon. The reaction mixture was quenched with methanol and concentrated. 3-Nitrophenylethyl amine was crystallized from the reaction mixture by adding oxalic acid (10 g, 0.08 mol). Yield 4.36 g, 85%.
후처리
- customThe reaction mixture was quenched with methanol
- concentrationconcentrated
- custom3-Nitrophenylethyl amine was crystallized from the reaction mixture
출처 및 근거
- ORD 기록
- ord-bd137f1d77d04b8889d7f0779a4293bb
- 출처 데이터셋
- uspto-grants-2003_07
- 특허 번호
- US06596734B1
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