Ammonia → Elpetrigine
반응식
[NH2:1][C:2]1[C:7]([C:8]2[CH:13]=[C:12]([Cl:14])[CH:11]=[C:10]([Cl:15])[C:9]=2[Cl:16])=[N:6][CH:5]=[C:4]([NH:17]C(=O)C)[N:3]=1.N>Cl.O>[NH2:1][C:2]1[C:7]([C:8]2[CH:13]=[C:12]([Cl:14])[CH:11]=[C:10]([Cl:15])[C:9]=2[Cl:16])=[N:6][CH:5]=[C:4]([NH2:17])[N:3]=1참가 물질
5
실험 절차
A suspension of 2-amino-6-acetamido-3-(2,3,5-trichlorophenyl)pyrazine (2.97 g, 8.96×10−3 mole) in 12M hydrochloric acid (1.31 ml) and water (4.04 ml) was fluxed for 1.75 hrs. The cooled mixture was then basified with 0.880 aqueous ammonia (5 ml) and extracted with chloroform (3×50 ml). The combined chloroform extracts were dried over anhydrous magnesium sulphate, filtered and the filtrate evaporated down in vacuo at 80° C. Yield 2.29 g (88%), M.p. 178-180° C.
후처리
- extractionextracted with chloroform (3×50 ml)
- dry with materialThe combined chloroform extracts were dried over anhydrous magnesium sulphate
- filtrationfiltered
- customthe filtrate evaporated down in vacuo at 80° C
출처 및 근거
- ORD 기록
- ord-e678911a49074da88ea60cab12336675
- 출처 데이터셋
- uspto-grants-2003_07
- 특허 번호
- US06599905B2
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