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1-benzoyl-5-nitro-1H-indole → HCID 9856121, 화합물

HRID 1359137
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HRID 1359137 반응식
[C:1]([N:9]1[C:17]2[C:12](=[CH:13][C:14]([N+:18]([O-])=O)=[CH:15][CH:16]=2)[CH:11]=[CH:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO.O1CCCC1.C([O-])=O.[NH4+].[Pd]>[C:1]([N:9]1[C:17]2[C:12](=[CH:13][C:14]([NH2:18])=[CH:15][CH:16]=2)[CH:11]=[CH:10]1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 1

HCID 98350711-benzoyl-5-nitro-1H-indole

생성물 1

HCID 9856121HCID 9856121, 화합물수율 56%

시약·촉매·용매 4

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매HCID 23938Palladium용매HCID 2723923Ammonium formate용매

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온도
30 °C

실험 절차

1-benzoyl-5-nitro-1H-indole (50 mg) was dissolved in a mixed solvent with methanol (2 ml) and tetrahydrofuran (2 ml), and ammonium formate of an excess amount and palladium/carbon (10%) of a catalytic amount were added. The reacted solution was stirred at around 30° C. for 30 minutes to complete the reduction, filtered through celite and then, concentrated under reduced pressure. Afterward, the residue was dissolved again in ethylacetate (10 ml), washed with water and brine, dried over anhydrous magnesium sulfate, concentrated under reduced pressure and then, triturated with isooctane and isopropyleter. As a result, the present compound (25 mg, productive yield 56%) was obtained as a solid.

후처리

  1. additionwere added
  2. filtrationfiltered through celite
  3. concentrationconcentrated under reduced pressure
  4. dissolutionAfterward, the residue was dissolved again in ethylacetate (10 ml)
  5. washwashed with water and brine
  6. dry with materialdried over anhydrous magnesium sulfate
  7. concentrationconcentrated under reduced pressure
  8. customtriturated with isooctane and isopropyleter
  9. customAs a result, the present compound (25 mg, productive yield 56%) was obtained as a solid

출처 및 근거

ORD 기록
ord-419943ebf2e0475d976431e20c35e3fa
출처 데이터셋
uspto-grants-2003_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06599929B2

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