Ethanol → 2-Methoxy-3-[2-thienyl(hydroxy)methyl]pyridine
반응식
[BH4-].[Na+].[CH3:3][O:4][C:5]1[C:10]([C:11]([C:13]2[S:14][CH:15]=[CH:16][CH:17]=2)=[O:12])=[CH:9][CH:8]=[CH:7][N:6]=1.C(O)C>O>[CH3:3][O:4][C:5]1[C:10]([CH:11]([C:13]2[S:14][CH:15]=[CH:16][CH:17]=2)[OH:12])=[CH:9][CH:8]=[CH:7][N:6]=1참가 물질
5
실험 절차
303 mg of sodium borohydride was added little by little to a solution containing 1.46 g of 2-methoxy-3-(2-thienylcarbonyl)pyridine and 10 ml of ethanol under ice-cooling. After stirring at room temperature for 2 hours, water was slowly added thereto and the mixture was extracted with ethyl acetate. The organic phase was washed with brine and the solvent was removed, to give 1.47 g of the target compound.
후처리
- temperaturecooling
- extractionthe mixture was extracted with ethyl acetate
- washThe organic phase was washed with brine
- customthe solvent was removed
출처 및 근거
- ORD 기록
- ord-cea2339f1f9f4f3696af161685ce6027
- 출처 데이터셋
- uspto-grants-2003_07
- 특허 번호
- US06599917B1
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