Thionyl Chloride → 4-[2-(2-Chloromethyl-phenoxy)-ethyl]-morpholine hydrochloride

HRID 1359665

반응식

HRID 1359665 반응식
S(Cl)([Cl:3])=O.[N:5]1([CH2:11][CH2:12][O:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[CH2:20]O)[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1>C(Cl)Cl>[ClH:3].[Cl:3][CH2:20][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[O:13][CH2:12][CH2:11][N:5]1[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 7164615[2-(2-Morpholinoethoxy)phenyl]methanol

생성물 1

HCID 181799524-[2-(2-Chloromethyl-phenoxy)-ethyl]-morpholine hydrochloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Thionyl chloride (5 mL, 2M in DCM) was added to a solution of [2-(2-morpholin-4-yl-ethoxy)-phenyl]-methanol (1.97 g, 8.3 mmol) in DCM (15 mL) at 0° C. The mixture was allowed to warm up to rt and stirred for 3 hours. The reaction was concentrated to give 4-[2-(2-chloromethyl-phenoxy)-ethyl]-morpholine hydrochloride.

후처리

  1. concentrationThe reaction was concentrated

출처 및 근거

ORD 기록
ord-be00cb7769404c78a5a43fa97f876643
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06599902B2

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