Hydrochloric Acid → 2-Amino-3-(3,4,5-trifluorophenyl)propanoic acid hydrochloride
반응식
C([O:3][C:4](=[O:30])[CH:5]([CH2:20][C:21]1[CH:26]=[C:25]([F:27])[C:24]([F:28])=[C:23]([F:29])[CH:22]=1)[N:6]=C(C1C=CC=CC=1)C1C=CC=CC=1)C.[ClH:31]>O>[ClH:31].[F:27][C:25]1[CH:26]=[C:21]([CH:22]=[C:23]([F:29])[C:24]=1[F:28])[CH2:20][CH:5]([C:4]([OH:30])=[O:3])[NH2:6]참가 물질
4
실험 절차
N-(Diphenylmethylene) (3,4,5-trifluoro)-D,L-Phenylalanine ethyl ester (1.33 g, 3.2 mmol) was suspended in water (15 mL) at 25° C. and treated with conc. hydrochloric acid (5 mL). The mixture was heated at reflux for 4 hrs and evaporated to dryness. The residue was triturated with diethyl ether (4×20 mL). The solid was filtered and dried to afford title compound (0.72 g)
후처리
- temperatureThe mixture was heated
- temperatureat reflux for 4 hrs
- customevaporated to dryness
- customThe residue was triturated with diethyl ether (4×20 mL)
- filtrationThe solid was filtered
- customdried
출처 및 근거
- ORD 기록
- ord-1df43f83820342d6a416547717f5b1e0
- 출처 데이터셋
- uspto-grants-2011_02
- 특허 번호
- US07879795B2
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