1,4-Dibromobutane → HCID 23160672, 화합물

HRID 1360397노트

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HRID 1360397 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[CH:4][CH:3]=1.Br[CH2:14][CH2:15][CH2:16][CH2:17]Br.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[N:1]1([C:2]2[CH:3]=[CH:4][C:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[CH:6][CH:7]=2)[CH2:17][CH2:16][CH2:15][CH2:14]1

참가 물질

5

반응물 3

HCID 80561,4-DibromobutaneHCID 11430Potassium CarbonateHCID 2761030Methyl 2-(4-aminophenyl)acetate

생성물 1

HCID 23160672HCID 23160672, 화합물수율 24.6%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
80 °C

실험 절차

Methyl 4-aminophenylacetate (0.4 g, 2.4 mmol), 1,4-dibromobutane (0.29 mL, 2.4 mmol) and potassium carbonate (0.34 g, 2.6 mmol) were dissolved in dimethylformamide (30 mL), and the mixture was stirred overnight at 80° C. The solvent was evaporated, and the residue was worked up according to a conventional method and purified by silica gel column chromatography to give the title compound (0.13 g, 0.59 mmol).

후처리

  1. customThe solvent was evaporated
  2. custompurified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-22e24d29648a4978bb12c9986712b8c0
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07879863B2

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