Hydrochloric Acid → 5-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(2-morpholin-4-ylethyl)thiophene-2-sulfonamide

HRID 1360860노트

반응식

HRID 1360860 반응식
[CH3:1][C:2]1[N:3]=[C:4]([NH:24]C(=O)C)[S:5][C:6]=1[C:7]1[S:8][C:9]([S:12]([NH:15][CH2:16][CH2:17][N:18]2[CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)(=[O:14])=[O:13])=[CH:10][CH:11]=1.Cl.CCO>>[NH2:24][C:4]1[S:5][C:6]([C:7]2[S:8][C:9]([S:12]([NH:15][CH2:16][CH2:17][N:18]3[CH2:19][CH2:20][O:21][CH2:22][CH2:23]3)(=[O:14])=[O:13])=[CH:10][CH:11]=2)=[C:2]([CH3:1])[N:3]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 11998430N-[4-methyl-5-(5-{[(2-morpholin-4-ylethyl)amino]sulfonyl}-2-thienyl)-1,3-thiazol-2-yl]acetamide

생성물 1

HCID 119983065-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(2-morpholin-4-ylethyl)thiophene-2-sulfonamide수율 111%

반응 조건

온도
90 °C

실험 절차

To N-[4-methyl-5-(5-{[(2-morpholin-4-ylethyl)amino]sulfonyl}-2-thienyl)-1,3-thiazol-2-yl]acetamide (9) (240 mg; 0.56 mmol; 1 eq) is added hydrochloric acid 1.25 M in EtOH (8.9 ml; 1.25 M; 11.2 mmol; 20 eq). The mixture is stirred overnight at 90° C. The mixture is cooled down to room temperature. The resulting precipitate is filtrated and rinsed with cold EtOH, affording Compound (6) as a yellowish solid (241.5 mg; 94%).

후처리

  1. temperatureThe mixture is cooled down to room temperature
  2. filtrationThe resulting precipitate is filtrated
  3. washrinsed with cold EtOH

출처 및 근거

ORD 기록
ord-5ee58035ca4d4ac6811c9b9396d36880
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07879888B2

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