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Ethanol → 4-Methyl-5-[5-[(4-methylpiperazin-1-yl)sulfonyl]-3-thienyl}-1,3-thiazol-2-amine

HRID 1360899
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HRID 1360899 반응식
[CH3:1][C:2]1[N:3]=[C:4]([NH:22]C(=O)C)[S:5][C:6]=1[C:7]1[CH:11]=[C:10]([S:12]([N:15]2[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]2)(=[O:14])=[O:13])[S:9][CH:8]=1.CCO>Cl>[CH3:1][C:2]1[N:3]=[C:4]([NH2:22])[S:5][C:6]=1[C:7]1[CH:11]=[C:10]([S:12]([N:15]2[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]2)(=[O:14])=[O:13])[S:9][CH:8]=1
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참가 물질

4

반응물 2

HCID 702EthanolHCID 11998679N-(4-methyl-5-{5-[(4-methylpiperazin-1-yl)sulfonyl]-3-thienyl}-1,3-thiazol-2-yl)acetamide

생성물 1

HCID 119989084-Methyl-5-[5-[(4-methylpiperazin-1-yl)sulfonyl]-3-thienyl}-1,3-thiazol-2-amine수율 124%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

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온도
90 °C

실험 절차

N-(4-methyl-5-{5-[(4-methylpiperazin-1-yl)sulfonyl]-3-thienyl}-1,3-thiazol-2-yl)acetamide (34) (978.5 mg; 2.44 mmol; 1 eq) is dissolved in hydrochloric acid 1.25 M in EtOH (39.09 ml; 1.25 M; 48.9 mmol; 20 eq). The mixture is stirred overnight at 90° C. It is cooled down to RT, filtrated, affording Compound (43) as a white solid (1084.3 mg; 91%).

후처리

  1. temperatureIt is cooled down to RT
  2. filtrationfiltrated

출처 및 근거

ORD 기록
ord-4a4ef8151ada4cb2b353775c322a40cc
출처 데이터셋
uspto-grants-2011_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07879888B2

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