Sodium Hydroxide → 4-(4-formylphenoxy)butanoic Acid

HRID 1360995노트

반응식

HRID 1360995 반응식
C([O:3][C:4](=[O:17])[CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]=[O:16])=[CH:11][CH:10]=1)C.[OH-].[Na+]>CO>[CH:15]([C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][CH2:6][CH2:5][C:4]([OH:17])=[O:3])=[CH:10][CH:11]=1)=[O:16]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 15517709Ethyl 4-(4-formylphenoxy)butanoate

생성물 1

HCID 35191904-(4-formylphenoxy)butanoic Acid수율 91.6%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

4-(4-Formylphenoxy)butyric acid ethyl ester (19.6 g, 75 mmol) was dissolved in methanol (250 mL) and 1N sodium hydroxide (100 mL) was added and the resulting mixture was stirred at room temperature for 16 hours. The organic solvent was evaporated in vacuo (40° C., 120 mBar) and the residue was acidified with 1N hydrochloric acid (110 mL). The mixture was filtered and washed with water and dried in vacuo to afford 14.3 g (91%) 4-(4-formylphenoxy)butyric acid as a solid. 1H-NMR (DMSO-d6): δ 1.99 (2H, p), 2.42 (2H, t), 4.13 (2H, t), 7.14 (2H, d), 7.88 (2H, d), 9.90 (1H, s), 12.2 (1H, bs). HPLC-MS (Method A): m/z=209 (M+1); Rt=2.19 min.

후처리

  1. customThe organic solvent was evaporated in vacuo (40° C., 120 mBar)
  2. filtrationThe mixture was filtered
  3. washwashed with water
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-e4414adef0194a80a6bf8b5aeac05f7c
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07879893B2

반응 노트

불러오는 중…