Ammonium Chloride → 3,3-Dimethylhex-5-en-1-ol

HRID 1361910노트

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HRID 1361910 반응식
[CH3:1][C:2]([CH3:9])([CH2:6][CH:7]=[CH2:8])[CH2:3][CH:4]=[O:5].[BH4-].[Na+].[Cl-].[NH4+]>C(O)C.O>[CH3:1][C:2]([CH3:9])([CH2:6][CH:7]=[CH2:8])[CH2:3][CH2:4][OH:5]

참가 물질

6

반응물 3

HCID 25517Ammonium ChlorideHCID 4311764Sodium borohydrideHCID 110623943,3-Dimethylhex-5-enal

생성물 1

HCID 114123903,3-Dimethylhex-5-en-1-ol

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

반응 조건

온도
5 °C

실험 절차

In a 1-L 4-necked round-bottom flask, 3,3-dimethylhex-5-enal (14.20 g; 0.113 mol) was dissolved in absolute ethanol (420 mL). Then the mixture was cooled to 5° C. in an ice-bath and, under nitrogen atmosphere, sodium borohydride (3.3 g; 0.087 mol) was added cautiously in 10 minutes. After the mixture had been stirred for 1 hour, it was poured into 5% ammonium chloride, diluted with water, and extracted with dichloromethane. Extracts were dried over sodium sulfate and evaporated, then the white solid was filtered away, while the pale yellow oil was distilled at 55-56° C. (4 mmHg) to give the title compound as a foul smelling, colorless liquid.

후처리

  1. extractionextracted with dichloromethane
  2. dry with materialExtracts were dried over sodium sulfate
  3. customevaporated
  4. filtrationthe white solid was filtered away, while the pale yellow oil
  5. distillationwas distilled at 55-56° C. (4 mmHg)

출처 및 근거

ORD 기록
ord-73084ee7c82147c59b4bb2b2c7415102
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07880014B2

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