Triethylamine → N-(1H-indol-3-ylmethyl)-N-methylacrylamide

HRID 1361964노트

반응식

HRID 1361964 반응식
[C:1](Cl)(=[O:4])[CH:2]=[CH2:3].[CH3:6][NH:7][CH2:8][C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[NH:11][CH:10]=1.CCN(CC)CC>C(Cl)Cl>[NH:11]1[C:12]2[C:17](=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:9]([CH2:8][N:7]([CH3:6])[C:1](=[O:4])[CH:2]=[CH2:3])=[CH:10]1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 13140Acryloyl chlorideHCID 96388N-Methyl-1H-indole-3-methanamine

생성물 1

HCID 22139147N-(1H-indol-3-ylmethyl)-N-methylacrylamide수율 80.7%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Acryloyl chloride (0.33 mL, 4.10 mmole) was added to a solution of 3-(methylaminomethyl)-1H-indole (0.60 g, 3.70 mmole) and Et3N (1.03 mL, 7.40 mmole) in CH2Cl2 (30 mL) at 0° C. The reaction was held at 0° C. for ten minutes, then was stirred overnight at RT. The solution was concentrated in vacuo and the residue was diluted with water. The solution was extracted with ethyl acetate, and the combined organic extracts were washed with brine and dried over Na2SO4. The title compound (0.64 g, 80%) was obtained as a light yellow solid: MS (ES) m/e 215 (M+H)+.

후처리

  1. waitThe reaction was held at 0° C. for ten minutes
  2. concentrationThe solution was concentrated in vacuo
  3. additionthe residue was diluted with water
  4. extractionThe solution was extracted with ethyl acetate
  5. washthe combined organic extracts were washed with brine
  6. dry with materialdried over Na2SO4

출처 및 근거

ORD 기록
ord-1db8ad2f3249479a9cc30891196aa35d
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07879872B2

반응 노트

불러오는 중…