O-Methylhydroxylamine → HCID 178526360, 화합물
반응식
[Cl:1][C:2]1[N:7]=[N:6][C:5](/[N:8]=[C:9](\Cl)/[C:10]([F:13])([F:12])[F:11])=[CH:4][CH:3]=1.C[O:16][NH2:17]>O1CCCC1>[Cl:1][C:2]1[N:7]=[N:6][C:5]([NH:8]/[C:9](=[N:17]\[OH:16])/[C:10]([F:13])([F:12])[F:11])=[CH:4][CH:3]=1참가 물질
4
실험 절차
To a solution of 4.5 g (18 mmol) of the crude product of Step B in 150 mL tetrahydrofuran was carefully added 2 mL aqueous 50% methoxyamine. The resulting solution was stirred under nitrogen at ambient temperature. After 1 h the solution was concentrated in vacuo then dissolved in 100 mL ethyl acetate and washed sequentially with saturated aqueous sodium bicarbonate solution and saturated aqueous brine (100 mL each). The organic phase was then dried over magnesium sulfate, filtered, and evaporated in vacuo to yield a crude oil.
후처리
- concentrationAfter 1 h the solution was concentrated in vacuo
- dissolutionthen dissolved in 100 mL ethyl acetate
- washwashed sequentially with saturated aqueous sodium bicarbonate solution and saturated aqueous brine (100 mL each)
- dry with materialThe organic phase was then dried over magnesium sulfate
- filtrationfiltered
- customevaporated in vacuo
- customto yield a crude oil
출처 및 근거
- ORD 기록
- ord-c1bed97882614b2bae1281e85b833931
- 출처 데이터셋
- uspto-grants-2011_02
- 특허 번호
- US07884104B2
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