Sodium Hydroxide → 7-(3,5-Bis(trifluoromethyl) phenoxy) heptanoic acid

HRID 1363875노트

반응식

HRID 1363875 반응식
[F:1][C:2]([F:26])([F:25])[C:3]1[CH:4]=[C:5]([CH:18]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:20]=1)[O:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([O:15]CC)=[O:14].[OH-].[Na+]>C(O)C>[F:1][C:2]([F:25])([F:26])[C:3]1[CH:4]=[C:5]([CH:18]=[C:19]([C:21]([F:23])([F:24])[F:22])[CH:20]=1)[O:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 86620562Ethyl 7-(3,5-bis(trifluoromethyl)phenoxy)heptanoate

생성물 1

HCID 866205637-(3,5-Bis(trifluoromethyl) phenoxy) heptanoic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Ethyl 7-(3,5-bis(trifluoromethyl)phenoxy)heptanoate was added to 95% ethanol and dissolved by reflux. The solution was then added with sodium hydroxide and further refluxed. The resulting crystals were filtered, washed with ethanol, and then added with dichloromethane and 1N hydrochloric acid. The solution was extracted twice with dichloromethane. After the organic layer was dried over anhydrous magnesium sulfate, the solvent was removed and the residue was purified by silica gel column chromatography to obtain 7-(3,5-bis(trifluoromethyl) phenoxy) heptanoic acid.

후처리

  1. dissolutiondissolved
  2. temperatureby reflux
  3. filtrationThe resulting crystals were filtered
  4. washwashed with ethanol
  5. additionadded with dichloromethane and 1N hydrochloric acid
  6. extractionThe solution was extracted twice with dichloromethane
  7. dry with materialAfter the organic layer was dried over anhydrous magnesium sulfate
  8. customthe solvent was removed
  9. customthe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-3296fdb9656e41619f7cbfa74f7bfa1b
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07887835B2

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