[NH:1]1[CH2:6][CH2:5][CH:4]([C@H:7]([NH:18][S@:19]([C:21]([CH3:24])([CH3:23])[CH3:22])=[O:20])[CH2:8][C:9]2[CH:14]=[C:13]([F:15])[C:12]([F:16])=[CH:11][C:10]=2[F:17])[CH2:3][CH2:2]1.C(Cl)CCl.C1C=CC2N(O)N=NC=2C=1.CCN(C(C)C)C(C)C.[CH:48]1([S:54][CH2:55][C:56](O)=[O:57])[CH2:53][CH2:52][CH2:51][CH2:50][CH2:49]1.CN(C=O)C>ClCCl>[CH:48]1([S:54][CH2:55][C:56]([N:1]2[CH2:6][CH2:5][CH:4]([C@H:7]([NH:18][S@:19]([C:21]([CH3:24])([CH3:23])[CH3:22])=[O:20])[CH2:8][C:9]3[CH:14]=[C:13]([F:15])[C:12]([F:16])=[CH:11][C:10]=3[F:17])[CH2:3][CH2:2]2)=[O:57])[CH2:53][CH2:52][CH2:51][CH2:50][CH2:49]1To (S)-2-Methyl-propane-2-sulfinic acid [(R)-1-piperidin-4-yl-2-(2,4,5-trifluoro-phenyl)-ethyl]-amide (200 mg, 0.552 mmol) in dichloromethane (1 mL) are added EDC (127 mg, 0.662 mmol), HOBt (97 mg, 0.718 mmol), DIPEA (283 uL, 1.656 mmol) and cyclohexylsulfanyl-acetic acid in DMF (2 mL, 1.2 mmol). After stirring at rt during 3 days, the mixture is washed with an aqueous 1N HCl solution, the organic phase is dried and evaporated to give the title compound.
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