3-Methoxyacetophenone → (+-)-1-(3-Methoxyphenyl)ethanol

HRID 1364407

반응식

HRID 1364407 반응식
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([O:10][CH3:11])[CH:5]=1)=[O:3].[BH4-].[Na+].[Cl-].[NH4+]>CO>[CH3:11][O:10][C:6]1[CH:5]=[C:4]([CH:2]([OH:3])[CH3:1])[CH:9]=[CH:8][CH:7]=1

참가 물질

5

반응물 3

HCID 114603-MethoxyacetophenoneHCID 25517Ammonium ChlorideHCID 4311764Sodium borohydride

생성물 1

HCID 90902(+-)-1-(3-Methoxyphenyl)ethanol수율 86.1%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 3-methoxyacetophenone (3 g; 20 mmol) in methanol (60 mL) is added sodium borohydride (1.13 g; 30 mmol) in four portions over one hour. The reaction is stirred at room temperature overnight, neutralized with saturated ammonium chloride, and extracted with ethyl acetate. The organics are separated, washed with water, and dried over magnesium sulfate. The solvent is removed to give 2.62 grams of 1-(3-methoxyphenyl)-ethanol.

후처리

  1. extractionextracted with ethyl acetate
  2. customThe organics are separated
  3. washwashed with water
  4. dry with materialdried over magnesium sulfate
  5. customThe solvent is removed

출처 및 근거

ORD 기록
ord-349df5ab7597479883ecf1d6154bd7e0
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07888366B2

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