Acetic Acid → 2-(4-Chlorophenyl)-2-oxoethyl acetate

HRID 1364479

반응식

HRID 1364479 반응식
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:5]=1Br)=[O:3].[C:12]([OH:15])(=[O:14])[CH3:13].C(N(CC)CC)C>C(#N)C>[Cl:10][C:7]1[CH:8]=[CH:9][C:4]([C:2](=[O:3])[CH2:1][O:15][C:12](=[O:14])[CH3:13])=[CH:5][CH:6]=1

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 8471TriethylamineHCID 47126441-(2-Bromo-4-chlorophenyl)ethanone

생성물 1

HCID 5872542-(4-Chlorophenyl)-2-oxoethyl acetate수율 90.1%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
4 °C

실험 절차

To a cooled (4° C.) and stirred solution of 2-bromo-4-chloroacetophenone (5.0 g, 21.41 mmol) and glacial acetic acid (2.8 mL, 49.25 mmol) in acetonitrile was added triethylamine (6.1 mL, 44.97 mmol). The reaction mixture was warmed to room temperature, than refluxed for 3 hours. The reaction mixture was extracted with ether, acetate, washed with 1N hydrochloric acid, brine, dried, and concentrated to yield 4.1 g of acetic acid 2-(4-chlorophenyl)-2-oxo-ethyl ester.

후처리

  1. temperatureThe reaction mixture was warmed to room temperature
  2. temperaturethan refluxed for 3 hours
  3. extractionThe reaction mixture was extracted with ether, acetate
  4. washwashed with 1N hydrochloric acid, brine
  5. customdried
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-519aa66d13344181be664316a80c9309
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07888366B2

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