2-Methoxy-1-phenylethanone → 2-Methoxy-1-phenylethan-1-ol

HRID 1364481노트

반응식

HRID 1364481 반응식
[CH3:1][O:2][CH2:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].[BH4-].[Na+]>C(O)C>[CH3:1][O:2][CH2:3][CH:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[OH:5]

참가 물질

4

반응물 2

HCID 776982-Methoxy-1-phenylethanoneHCID 4311764Sodium borohydride

생성물 1

HCID 5722942-Methoxy-1-phenylethan-1-ol수율 78.9%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a stirred solution of 2-methoxy-1-phenylethanone (1.0 g, 6.66 mmol) in ethanol was added sodium borohydride (0.28 g, 7.32 mmol). The reaction mixture was stirred at room temperature for 1 hour. The reaction mixture was quenched with sat. ammonium chloride solution, concentrated. Extracted with ethyl acetate, washed with brine, dried, and concentrated to yield 0.8 g of 2-methoxy-1-phenylethanol.

후처리

  1. customThe reaction mixture was quenched with sat. ammonium chloride solution
  2. concentrationconcentrated
  3. extractionExtracted with ethyl acetate
  4. washwashed with brine
  5. customdried
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-6e2bde9bd215416492fcfa59e9a45d5b
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07888366B2

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