Morpholine → 4-((4-(Bromomethyl)phenyl)sulfonyl)morpholine

HRID 1364585

반응식

HRID 1364585 반응식
[Br:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9](Cl)(=[O:11])=[O:10])=[CH:5][CH:4]=1.C(N(CC)CC)C.[NH:20]1[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1>ClCCl.Cl>[Br:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([N:20]2[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)(=[O:11])=[O:10])=[CH:5][CH:4]=1

참가 물질

6

반응물 3

HCID 8083MorpholineHCID 8471TriethylamineHCID 27344094-(Bromomethyl)benzenesulfonyl chloride

생성물 1

HCID 27796804-((4-(Bromomethyl)phenyl)sulfonyl)morpholine

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 6344Dichloromethane용매

실험 절차

To a stirring solution of commercially-available 4-bromomethyl benzenesulfonyl chloride (1.0 g, 3.71 mmol) in dichloromethane (8 ml) at 0° C. under an argon atmosphere, is added triethylamine (0.575 ml, 4.1 mmol), in one portion, followed by morpholine (0.359 ml, 4.1 mmol). The reaction mixture is stirred for 20 h, warming up slowly to room temperature. The reaction mixture is then diluted with 2N HCl aq (40 ml) and extracted in dichloromethane (20 ml), dried (MgSO4) and evaporated to dryness in vacuo to afford the title compound. No mass ion detected.

후처리

  1. extractionextracted in dichloromethane (20 ml)
  2. dry with materialdried (MgSO4)
  3. customevaporated to dryness in vacuo

출처 및 근거

ORD 기록
ord-1e89f22503134cad9b9f17ec320c3ec8
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07888383B2

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