N-bromobutanimide → HCID 178470082, 화합물

HRID 1365044노트

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HRID 1365044 반응식
[CH2:1]([O:3][C:4]([C:6]1[C:7]([OH:14])=[N:8][N:9]([CH:11]([CH3:13])[CH3:12])[CH:10]=1)=[O:5])[CH3:2].[Br:15]N1C(=O)CCC1=O>ClCCl>[CH2:1]([O:3][C:4]([C:6]1[C:7]([OH:14])=[N:8][N:9]([CH:11]([CH3:13])[CH3:12])[C:10]=1[Br:15])=[O:5])[CH3:2]

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 178469772Ethyl 3-hydroxy-1-isopropylpyrazole-4-carboxylate

생성물 1

HCID 178470082HCID 178470082, 화합물수율 40.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

3-Hydroxy-1-isopropylpyrazole-4-carboxylic acid ethyl ester (10.5 g) was dissolved in dichloromethane (100 mL), and N-bromosuccinimide (14.1 g) was added to the solution under ice cooling. The mixture was stirred at room temperature for 6 hours. The solvent was removed under reduced pressure, and the obtained residue was purified by column chromatography on silica gel (eluent: ethyl acetate/hexane=1/5) to give the title compound (5.9 g)

후처리

  1. customThe solvent was removed under reduced pressure
  2. customthe obtained residue was purified by column chromatography on silica gel (eluent: ethyl acetate/hexane=1/5)

출처 및 근거

ORD 기록
ord-58a6ea5308734d1a98b28e655a0a8aec
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07888487B2

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