1-Bromo-2-methylpropane → HCID 57762509, 화합물

반응식

[I:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:14]=[CH:13][CH:12]=[CH:11][N:10]=2)=[CH:4][CH:3]=1.[CH2:15](Br)[CH:16]([CH3:18])[CH3:17].[H-].[Na+]>>[I:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]([CH2:15][CH:16]([CH3:18])[CH3:17])[C:9]2[N:10]=[CH:11][CH:12]=[CH:13][N:14]=2)=[CH:6][CH:7]=1

참가 물질

반응물 3

HCID 65551-Bromo-2-methylpropane

HCID 24758Sodium hydride

HCID 57762548N-(4-iodophenyl)pyrimidin-2-amine

생성물 1

HCID 57762509HCID 57762509, 화합물수율 93.6%

실험 절차

In the same manner as in Reference Example 13, N-(4-iodophenyl)pyrimidin-2-amine (150 mg) and isobutyl bromide (83 mg) were reacted in the presence of sodium hydride to obtain N-(4-iodophenyl)-N-isobutylpyrimidin-2-amine (167 mg).

출처 및 근거

ORD 기록: ord-4d0d9f1a7b274e6c815ef07e0d1cec84
출처 데이터셋: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07893046B2

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