Lithium Hydroxide → 5-Bromo-2-[(4-methoxy-benzylamino)-methyl]-furan-3-carboxylic acid

HRID 1366216노트

반응식

HRID 1366216 반응식
C[O:2][C:3]([C:5]1[CH:9]=[C:8]([Br:10])[O:7][C:6]=1[CH2:11][NH:12][CH2:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=1)=[O:4].[Li+].[OH-].C1COCC1>O>[Br:10][C:8]1[O:7][C:6]([CH2:11][NH:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)=[C:5]([C:3]([OH:4])=[O:2])[CH:9]=1

참가 물질

5

반응물 3

HCID 3939Lithium HydroxideHCID 8028TetrahydrofuranHCID 590231235-Bromo-2-[(4-methoxy-benzylamino)-methyl]-furan-3-carboxylic acid methyl ester

생성물 1

HCID 590230235-Bromo-2-[(4-methoxy-benzylamino)-methyl]-furan-3-carboxylic acid수율 100.1%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 5-bromo-2-[(4-methoxy-benzylamino)-methyl]-furan-3-carboxylic acid methyl ester (643.8 mg, 1.82 mmol) and LiOH (115 mg, 2.74 mmol) in 1:1 THF:H2O (30 mL) is refluxed for 3 hours. The solvent is evaporated in vacuo to afford the title compound (620 mg, 99%) which is used in the next step without further purification.

후처리

  1. customThe solvent is evaporated in vacuo

출처 및 근거

ORD 기록
ord-66c653109b6041a7ba34ea86390692ec
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07893058B2

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