Hydrochloric Acid → HCID 178448898, 화합물

HRID 1366542노트

반응식

HRID 1366542 반응식
CC(OC([N:8](C(OC(C)(C)C)=O)[N:9]([C:17]1[C:22]([F:23])=[C:21]([NH:24][CH2:25][C:26]([CH3:34])([N:28]2[CH2:33][CH2:32][O:31][CH2:30][CH2:29]2)[CH3:27])[N:20]=[C:19]([Cl:35])[N:18]=1)C(OC(C)(C)C)=O)=O)(C)C.Cl>CO.O1CCOCC1>[Cl:35][C:19]1[NH:20][C:21]([NH:24][CH2:25][C:26]([CH3:34])([N:28]2[CH2:33][CH2:32][O:31][CH2:30][CH2:29]2)[CH3:27])=[C:22]([F:23])[C:17](=[N:9][NH2:8])[N:18]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 86636980Tris(1,1-dimethylethyl) 2-(2-chloro-5-fluoro-6-{[2-methyl-2-(4-morpholinyl)propyl]amino}-4-pyrimidinyl)-1,1,2-hydrazinetricarboxylate

생성물 1

HCID 178448898HCID 178448898, 화합물수율 83.1%

시약·촉매·용매 2

HCID 887Methanol용매HCID 312751,4-Dioxane용매

실험 절차

To a suspension of tris(1,1-dimethylethyl)2-(2-chloro-5-fluoro-6-{[2-methyl-2-(4-morpholinyl)propyl]amino}-4-pyrimidinyl)-1,1,2-hydrazinetricarboxylate (0.578 g, 0.94 mmol) in MeOH (8 mL) was added 4M HCl in 1,4-dioxane (8 mL), and the resulting mixture was stirred at room temperature overnight. The solvent was removed in vacuo, and the crude residue was treated with an aqueous K2CO3 extractive workup to provide 2-chloro-5-fluoro-6-{[2-methyl-2-(4-morpholinyl)propyl]amino}-4(1H)-pyrimidinone hydrazone as a brown oil (0.249 g). LCMS: (M+H)+=319.2.

후처리

  1. customThe solvent was removed in vacuo
  2. additionthe crude residue was treated with an aqueous K2CO3 extractive workup

출처 및 근거

ORD 기록
ord-8108465012a749ea848552982a4231f8
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07893056B2

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