4-Methylmorpholine → methyl (2R)-1-(N-{[(phenylmethyl)oxy]carbonyl}glycyl)-2-piperidinecarboxylate

To a solution of methyl (2R)-2-piperidinecarboxylate hydrochloride (1.0 g, 5.56 mmol) and HOBt (0.90 g, 6.67 mmol) in CH2Cl2 (20 mL) was added 4-methylmorpholine (2.44 mL, 22.24 mmol), N-{[(phenylmethyl)oxy]carbonyl}glycine (1.16 g, 5.56 mmol), and EDCI (1.28 g, 6.67 mmol). After stirring overnight, the solution was washed 6 N aq. HCl (100 mL) and water (100 mL). The aqueous layer was extracted with CH2Cl2 (3×50 mL). The combined organic layers were washed with water (50 mL) and brine (50 mL), and then dried over anhydrous MgSO4 and concentrated in vacuo to provide methyl (2R)-1-(N-{[(phenylmethyl)oxy]carbonyl}glycyl)-2-piperidinecarboxylate (2.029 g, 99%). LCMS: (M+H)+: 335.1.

1. washthe solution was washed 6 N aq. HCl (100 mL) and water (100 mL)
2. extractionThe aqueous layer was extracted with CH2Cl2 (3×50 mL)
3. washThe combined organic layers were washed with water (50 mL) and brine (50 mL)
4. dry with materialdried over anhydrous MgSO4
5. concentrationconcentrated in vacuo

ORD 기록

ord-48fd90e5d0b4451a8eac6ebad9ec5691

출처 데이터셋

uspto-grants-2011_02

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US07893056B2