Hydrochloric Acid → (S)-N,N-Dimethyl(pyrrolidin-2-yl)methanamine hydrochloride
반응식
[CH3:1][N:2]([CH3:16])[CH2:3][C@@H:4]1[CH2:8][CH2:7][CH2:6][N:5]1CC1C=CC=CC=1.[ClH:17]>CO>[ClH:17].[CH3:1][N:2]([CH3:16])[CH2:3][C@@H:4]1[CH2:8][CH2:7][CH2:6][NH:5]1참가 물질
4
실험 절차
N,N-Dimethyl-1-[(2S)-1-(phenylmethyl)-2-pyrrolidinyl]methanamine (3.730 g, 17.08 mmol) was dissolved in a mixture of MeOH (100 mL) and 1N HCl (35 mL, 34.16 mmol), degassed and placed under argon. 10% Pd/C (1.119 g) was added, and the contents were thoroughly degassed and placed under a hydrogen balloon for 2 h. The contents were then degassed, and the Pd/C was removed by filtration through a fiberglass filter, washing with MeOH. The filtrate was concentrated in vacuo to provide pure N,N-dimethyl-1-[(2S)-2-pyrrolidinyl]methanamine hydrochloride (3.3701 g, >99%). LCMS: (M+H)+: 129.1.
후처리
- customdegassed
- addition10% Pd/C (1.119 g) was added
- customthe contents were thoroughly degassed
- customfor 2 h
- customThe contents were then degassed
- customthe Pd/C was removed by filtration through a fiberglass
- filtrationfilter
- washwashing with MeOH
- concentrationThe filtrate was concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-440e6e5a58ad45cdabb196372a586223
- 출처 데이터셋
- uspto-grants-2011_02
- 특허 번호
- US07893056B2
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