Water → 2,2-diethoxyethyl Benzoate

HRID 13681

반응식

HRID 13681 반응식
[CH2:1]([O:3][CH:4]([O:7][CH2:8][CH3:9])[CH2:5]Cl)[CH3:2].[C:10]([O-:18])(=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[K+].CN(C=O)C.O>C(OCC)(=O)C>[CH2:1]([O:3][CH:4]([O:7][CH2:8][CH3:9])[CH2:5][O:18][C:10](=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH3:2]

참가 물질

6

반응물 4

HCID 962WaterHCID 6228DimethylformamideHCID 121282-Chloro-1,1-diethoxyethaneHCID 23661960Potassium Benzoate

생성물 1

HCID 118172582,2-diethoxyethyl Benzoate수율 30%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Chloroacetaldehyde diethyl acetal (1.9 g), potassium benzoate (2.0 g) and DMF (20 mL) were placed in a three-neck flask, followed by refluxing. Twenty hours later, the reaction mixture was cooled to room temperature, and water (60 mL) and ethyl acetate (80 mL) were added thereto, followed by stirring. After filtration and separation, the organic layer was concentrated and thereby yielded the target compound (0.69 g) in a yield of 30%.

후처리

  1. temperatureby refluxing
  2. filtrationAfter filtration and separation
  3. concentrationthe organic layer was concentrated

출처 및 근거

ORD 기록
ord-ab04dd03fbe84d7fa44f135c7f0202f5
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728152B2

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