Formic Acid → HCID 178487492, 화합물

HRID 1368509

반응식

HRID 1368509 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([C:13]([C:15]1[N:16]=[CH:17][N:18](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH:19]=1)=[O:14])[CH:7]=[CH:6]2.C(O)=O.[CH2:42]1[CH2:46]OC[CH2:43]1>>[NH:18]1[CH:19]=[C:15]([C:13]([C:8]2[CH:7]=[CH:6][C:5]3[C:10](=[CH:11][CH:12]=[C:3]([O:2][CH3:1])[CH:4]=3)[CH:9]=2)([OH:14])[CH:42]([CH3:46])[CH3:43])[N:16]=[CH:17]1

참가 물질

4

반응물 3

HCID 284Formic AcidHCID 8028TetrahydrofuranHCID 11733735(6-Methoxynaphthalen-2-yl)-(1-trityl-1H-imidazol-4-yl)ketone

생성물 1

HCID 178487492HCID 178487492, 화합물

반응 조건

온도
50 °C

실험 절차

(6-Methoxynaphthalen-2-yl)-(1-trityl-1H-imidazol-4-yl)ketone (15.0 g) was dissolved in THF (80 ml). To the solution was added 90% formic acid (20 ml), and the mixture was stirred at 50° C. for 2 h. After removal of the solvents by evaporation, 1N-hydrochloric acid (60 ml) was added and the precipitate was filtered off. The filtrate was washed with ether, and neutralized with potassium carbonate. The resulting precipitate was collected by filtration, dried under reduced pressure to give the titled compound (7.54 g) as a colorless solid.

후처리

  1. customAfter removal of the solvents
  2. customby evaporation, 1N-hydrochloric acid (60 ml)
  3. additionwas added
  4. filtrationthe precipitate was filtered off
  5. washThe filtrate was washed with ether
  6. filtrationThe resulting precipitate was collected by filtration
  7. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-6db7d0a9eed2440bbe8e310b76c2ae5a
출처 데이터셋
uspto-grants-2003_06
특허 번호
US06573289B1

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