1-(6-Acetoxynaphthalen-2-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol → HCID 178475354, 화합물

HRID 1368523

반응식

HRID 1368523 반응식
[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[CH:11]=[C:10]([C:15]([C:20]1[N:21]=[CH:22][N:23](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH:24]=1)([OH:19])[CH:16]([CH3:18])[CH3:17])[CH:9]=[CH:8]2)(=[O:3])[CH3:2]>C(O)(=O)C.[C].[Pd]>[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[CH:11]=[C:10]([C:15]([C:20]1[N:21]=[CH:22][NH:23][CH:24]=1)([OH:19])[CH:16]([CH3:18])[CH3:17])[CH:9]=[CH:8]2)(=[O:3])[CH3:2]

참가 물질

4

반응물 1

HCID 220183421-(6-Acetoxynaphthalen-2-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol

생성물 1

HCID 178475354HCID 178475354, 화합물수율 69.9%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 176Acetic Acid용매

반응 조건

온도
50 °C

실험 절차

1-(6-Acetoxynaphthalen-2-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol (0.25 g) was dissolved in acetic acid (20 ml). To the mixture was added 10% palladium carbon (0.1 g). The mixture was stirred at 50° C. for 2 h under hydrogen atmosphere. The catalyst was filtered off, and filtrate was concentrated. The residue was purified by silica gel chromatography (eluent; dichloromethane-methanol=10:1) to give the titled compound (0.1 g) as a colorless solid.

후처리

  1. filtrationThe catalyst was filtered off
  2. concentrationfiltrate was concentrated
  3. customThe residue was purified by silica gel chromatography (eluent; dichloromethane-methanol=10:1)

출처 및 근거

ORD 기록
ord-294df26305144dcbba769b9e9633acc5
출처 데이터셋
uspto-grants-2003_06
특허 번호
US06573289B1

연결된 노트

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