Malonic Acid → 3-Amino-3-(4-(trifluoromethoxy)phenyl)propanoic acid
반응식
[F:1][C:2]([F:13])([F:12])[O:3][C:4]1[CH:11]=[CH:10][C:7]([CH:8]=O)=[CH:6][CH:5]=1.[C:14]([OH:20])(=[O:19])[CH2:15]C(O)=O.C([O-])(=O)C.[NH4+:25]>C(O)C>[NH2:25][CH:8]([C:7]1[CH:10]=[CH:11][C:4]([O:3][C:2]([F:13])([F:12])[F:1])=[CH:5][CH:6]=1)[CH2:15][C:14]([OH:20])=[O:19]참가 물질
5
실험 절차
10.5 g of 4-(trifluoromethoxy)benzaldehyde, 5.72 g of malonic acid, 8.5 g of ammonium acetate and 40 ml of ethanol are boiled under reflux for 8 hours and stirred at room temperature overnight. The cooled reaction mixture is then filtered with suction, washed with ethanol and ether and dried in air. 3-amino-3-(4-trifluoromethoxyphenyl)propionic acid is obtained, melting point 258-260°.
후처리
- temperatureunder reflux for 8 hours
- customThe cooled reaction mixture
- filtrationis then filtered with suction
- washwashed with ethanol and ether
- customdried in air
출처 및 근거
- ORD 기록
- ord-f0605d84d90b43599d714c85a74a8d39
- 출처 데이터셋
- uspto-grants-2003_06
- 특허 번호
- US06576637B1
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