N-Iodosuccinimide → 7-Iodo-4-(trifluoromethyl)-1H-indole-2,3-dione
반응식
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:4]=1[C:5](=[O:13])[C:6](=[O:12])[NH:7]2.[I:16]N1C(=O)CCC1=O>OS(O)(=O)=O>[I:16][C:9]1[CH:10]=[CH:11][C:3]([C:2]([F:1])([F:14])[F:15])=[C:4]2[C:8]=1[NH:7][C:6](=[O:12])[C:5]2=[O:13]참가 물질
4
반응 조건
- 온도
- 40 °C
실험 절차
A mixture of 4-trifluoromethylisatin (450 mg, 2.09 mmol) and N-iodosuccinimide (800 mg, 3.72 mmol) in conc. H2SO4 (5 mL) was stirred for 6 h at 40° C. and poured into crushed ice. The mixture was extracted with ethyl acetate and the extracts were washed with aqueous Na2SO3, dried over MgSO4, and concentrated. The residue was purified by silica gel column chromatography with 3:1 hexane/ethyl acetate to give the title compound (296 mg, 42%).
후처리
- additionpoured
- custominto crushed ice
- extractionThe mixture was extracted with ethyl acetate
- washthe extracts were washed with aqueous Na2SO3
- dry with materialdried over MgSO4
- concentrationconcentrated
- customThe residue was purified by silica gel column chromatography with 3:1 hexane/ethyl acetate
출처 및 근거
- ORD 기록
- ord-200d528cbf4d4f4faa879521d7acd9e1
- 출처 데이터셋
- uspto-grants-2003_06
- 특허 번호
- US06576656B1
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