7-Nitroindole → 7-Aminoindole

HRID 13692

반응식

HRID 13692 반응식
[N+:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11][CH:10]=[CH:9]2)([O-])=O.C([O-])=O.[NH4+]>C(O)C.[Pd]>[NH:11]1[C:12]2[C:8](=[CH:7][CH:6]=[CH:5][C:4]=2[NH2:1])[CH:9]=[CH:10]1

참가 물질

5

반응물 2

HCID 233967-NitroindoleHCID 2723923Ammonium formate

생성물 1

HCID 1116347-Aminoindole수율 99%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

Dissolve 7-nitroindole in ethanol and add ammonium formate (10 equivalents) and a catalytic amount of 10% palladium on carbon. Heat the mixture to reflux for 1 hr before cooling, filter through celite, and evaporate to provide the product as a purple solid (99%).

후처리

  1. temperatureHeat the mixture
  2. temperatureto reflux for 1 hr
  3. temperaturebefore cooling
  4. filtrationfilter through celite
  5. customevaporate

출처 및 근거

ORD 기록
ord-d66e2b89479b4a10883eee173cc6ba93
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728150B2

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