Hydrochloric Acid → HCID 178505547, 화합물
반응식
[Br:1][C:2]1[N:3]=[C:4]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[N:5](COCC[Si](C)(C)C)[CH:6]=1.Cl.O>CCO>[Br:1][C:2]1[N:3]=[C:4]([C:15]2[CH:16]=[CH:17][C:18]([F:21])=[CH:19][CH:20]=2)[NH:5][CH:6]=1참가 물질
5
실험 절차
4-Bromo-2-(4-fluorophenyl)-1-(2-trimethylsilanyl-ethoxymethyl)imidazole (3.4 g; 9 mmol) is dissolved in EtOH (34 ml) and HCl conc. (37%; 34 ml) and heated to 55 C for 1 h. Water is added to the reaction mixture and the aqueous phase extracted three times with ethyl acetate. The combined organic phases are washed with 2N Na2CO3 and saturated NaCl-solution, dried over Na2SO4, filtered and evaporated to dryness to yiled the title compound as colorless crystals (2.1 g, 92%).
후처리
- extractionthe aqueous phase extracted three times with ethyl acetate
- washThe combined organic phases are washed with 2N Na2CO3 and saturated NaCl-solution
- dry with materialdried over Na2SO4
- filtrationfiltered
- customevaporated to dryness to yiled the title compound as colorless crystals (2.1 g, 92%)
출처 및 근거
- ORD 기록
- ord-a664c80e776449bea362bb902320893f
- 출처 데이터셋
- uspto-grants-2003_06
- 특허 번호
- US06579874B2
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