Hydrochloric Acid → 6-(5-Chloro-3-methyl-benzofuran-2-sulfonyl)-2H-pyridazin 2H-pyridazin-3-one

HRID 1369465노트

반응식

HRID 1369465 반응식
C[O:2][C:3]1[N:4]=[N:5][C:6]([S:9]([C:12]2[O:13][C:14]3[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][C:15]=3[C:16]=2[CH3:17])(=[O:11])=[O:10])=[CH:7][CH:8]=1.Cl>O1CCOCC1>[Cl:22][C:19]1[CH:20]=[CH:21][C:14]2[O:13][C:12]([S:9]([C:6]3[NH:5][NH:4][CH:3]=[CH:8][CH:7]=3)(=[O:10])=[O:11])=[C:16]([CH3:17])[C:15]=2[CH:18]=1.[N:5]1[NH:4][C:3](=[O:2])[CH:8]=[CH:7][CH:6]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 99458133-Methoxy-6-(5-chloro-3-methyl-benzofuran-2-sulfonyl)-pyridazine

생성물 1

HCID 690493596-(5-Chloro-3-methyl-benzofuran-2-sulfonyl)-2H-pyridazin 2H-pyridazin-3-one

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

반응 조건

온도
100 °C

실험 절차

A mixture of 3-methoxy-6-(5-chloro-3-methyl-benzofuran-2-sulfonyl)-pyridazine (22.2 mmol, 7.5 g), conc. HCl (5 mL), and dioxane (50 mL) was heated at 100° C. for 2 hours. The reaction mixture was cooled and evaporated to dryness. Water (20 mL) was added to the residue. The resulting precipitate was collected and crystallized from ethanol to obtain the desired product: 6-(5-chloro-3-methyl-benzofuran-2-sulfonyl)-2H-pyridazin-2H-pyridazin-3-one (89%, 6.42 g).

후처리

  1. temperatureThe reaction mixture was cooled
  2. customevaporated to dryness
  3. additionWater (20 mL) was added to the residue
  4. customThe resulting precipitate was collected
  5. customcrystallized from ethanol

출처 및 근거

ORD 기록
ord-29d7953f25b44b04be44efe3378627bf
출처 데이터셋
uspto-grants-2003_06
특허 번호
US06579879B2

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