Dimethylformamide → HCID 178510366, 화합물
반응식
P(Cl)(Cl)(Cl)=O.CN(C)C=O.[OH:11][C:12]1[C:20]([N+:21]([O-:23])=[O:22])=[CH:19][C:15]([C:16]([NH2:18])=O)=[CH:14][N:13]=1>O>[C:16]([C:15]1[CH:19]=[C:20]([N+:21]([O-:23])=[O:22])[C:12]([OH:11])=[N:13][CH:14]=1)#[N:18]참가 물질
5
실험 절차
Phosphorus oxychloride (2.99 mL) was added dropwise to N,N-dimethylformamide (49 mL) at 0° C., and the mixture was stirred at the same temperature for 15 minutes. Then 6-hydroxy-5-nitronicotinamide (4.9 g) was added portionwise to the mixture, and the reaction mixture was stirred at 50° C. for an hour. Water was added to the reaction mixture at 0° C., and the resulting precipitate was collected by filtration in vacuo. The obtained solid was washed with water to give 5-cyano-2-hydroxy-3-nitropyridine (3.17 g) as a pale brown solid.
후처리
- stirringthe reaction mixture was stirred at 50° C. for an hour
- filtrationthe resulting precipitate was collected by filtration in vacuo
- washThe obtained solid was washed with water
출처 및 근거
- ORD 기록
- ord-31c59caaa8a0418b879aa3975ec6842f
- 출처 데이터셋
- uspto-grants-2003_06
- 특허 번호
- US06582351B1
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