Nitric Acid → 3-Bromo-2-nitrothiophene
반응식
[N+:1]([O-:4])(O)=[O:2].C(OC(=O)C)(=O)C.[Br:12][C:13]1[CH:17]=[CH:16][S:15][CH:14]=1>C(O)(=O)C>[Br:12][C:13]1[CH:17]=[CH:16][S:15][C:14]=1[N+:1]([O-:4])=[O:2]참가 물질
5
실험 절차
7.4 ml of fuming nitric acid was slowly added to 92.1 ml of acetic acid under ice-cooling, followed by stirring for 10 minutes, and a solution of 52.1 ml of acetic anhydride containing 25 g of 3-bromothiophene was slowly added in such a manner that the bulk temperature did not exceed 10° C., followed by stirring at 10 ° C. for 2 hours. Ice was added to the reaction solution, and the resulting crystals were collected by filtration, and washed with water and diethyl ether/n-hexane=1/5 successively, to give 17.4 g of the title compound.
후처리
- temperaturecooling
- customdid not exceed 10° C.
- stirringby stirring at 10 ° C. for 2 hours
- additionIce was added to the reaction solution
- filtrationthe resulting crystals were collected by filtration
- washwashed with water and diethyl ether/n-hexane=1/5 successively
출처 및 근거
- ORD 기록
- ord-4f032b09762d403b9ad74e2a78a53d80
- 출처 데이터셋
- uspto-grants-2003_06
- 특허 번호
- US06583138B1
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