Ethanol → 6-Ethoxy-3-nitropyridin-2-amine

HRID 1370194노트

반응식

HRID 1370194 반응식
[H-].[Na+].[NH2:3][C:4]1[C:9]([N+:10]([O-:12])=[O:11])=[CH:8][CH:7]=[C:6](Cl)[N:5]=1.[CH2:14]([OH:16])[CH3:15]>>[NH2:3][C:4]1[C:9]([N+:10]([O-:12])=[O:11])=[CH:8][CH:7]=[C:6]([O:16][CH2:14][CH3:15])[N:5]=1

참가 물질

4

반응물 3

HCID 702EthanolHCID 24758Sodium hydrideHCID 27240356-Chloro-3-nitropyridin-2-ylamine

생성물 1

HCID 132457716-Ethoxy-3-nitropyridin-2-amine

실험 절차

2.4 g of 60% sodium hydride was slowly added to 100 ml of ethanol and stirred as it was at room temperature for 10 minutes. 10 g of 2-amino-6-chloro-3-nitropyridine was added thereto and reacted at room temperature for 30 minutes. After concentration, water was added thereto, and it was extracted with ethyl acetate. It was washed with water and brine sucsessively, and dried over anhydrous sodium sulfate. After concentration, 9.7 g of the title compound was obtained.

후처리

  1. customreacted at room temperature for 30 minutes
  2. concentrationAfter concentration, water
  3. additionwas added
  4. extractionit was extracted with ethyl acetate
  5. washIt was washed with water and brine sucsessively
  6. dry with materialdried over anhydrous sodium sulfate
  7. concentrationAfter concentration

출처 및 근거

ORD 기록
ord-cb8a7275956a4321b4f8d8517092a4ce
출처 데이터셋
uspto-grants-2003_06
특허 번호
US06583138B1

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