Hydrochloric Acid → 1-{(2S)-4-[1-(3,4-Dichlorophenyl)ethyl]morpholin-2-yl}methanamine Dihydrochloride

HRID 1371395노트

반응식

HRID 1371395 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]([N:11]2[CH2:16][CH2:15][O:14][C@@H:13]([CH2:17][NH:18]C(=O)OC(C)(C)C)[CH2:12]2)[CH3:10])[CH:5]=[CH:6][C:7]=1[Cl:8].[ClH:26].CO>O1CCOCC1>[ClH:1].[ClH:26].[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]([N:11]2[CH2:16][CH2:15][O:14][C@@H:13]([CH2:17][NH2:18])[CH2:12]2)[CH3:10])[CH:5]=[CH:6][C:7]=1[Cl:8]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 86760345tert-Butyl {(2S)-4-[1-(3,4-dichlorophenyl)ethyl]morpholin-2-yl}methylcarbamate

생성물 1

HCID 690592951-{(2S)-4-[1-(3,4-Dichlorophenyl)ethyl]morpholin-2-yl}methanamine Dihydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

Intermediate 32 was treated with 4M hydrogen chloride in dioxane (15 ml) and the solution stirred for 2 h at room temperature. The solution was treated with methanol (20 ml) and concentrated in vacuo to give the title compound as an off-white solid (1.53 g).

후처리

  1. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-682c33b79d4a4dcdad9b4a77aeb42c57
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07157457B2

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